Prexasertib lactate - CAS 2781996-46-9

Prexasertib lactate is the lactate salt form of Prexasertib and functions as a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor with a Ki of 0.9 nM and an IC50 of less than 1 nM. It also inhibits CHK2 (IC50 = 8 nM) and RSK1 (IC50 = 9 nM) . This compound induces double-strand DNA breaks and replication stress, leading to apoptosis (cell death), and exhibits antitumor activity.

DNA/RNA Synthesis, Chk, Apoptosis

Cell Cycle/Checkpoint, DNA Damage/DNA Repair, Apoptosis

2781996-46-9

C21H25N7O5

455.47

[C@@H](C(O)=O)(C)O.O(CCCN)C1=C(C(OC)=CC=C1)C2=CC(NC=3C=NC(C#N)=CN3)=NN2

-20°C

Ice Packs

Small Compound