Prexasertib mesylate - CAS 1234015-55-4

Prexasertib is a potent and selective Chk1/Chk2 inhibitor. Prexasertib increases the effectiveness of conventional therapy in B-/T- cell progenitor acute lymphoblastic leukemia. LY2606368 causes replication catastrophe and antitumor effects through CHK1-dependent mechanisms. Treatment of cells with LY2606368 results in the rapid appearance of TUNEL and pH2AX-positive double-stranded DNA breaks in the S-phase cell population.

Chk, Apoptosis, Others, DNA/RNA Synthesis

Others, Apoptosis, DNA Damage/DNA Repair, Cell Cycle/Checkpoint

1233956

C19H23N7O5S

461.49

N#CC1=NC=C(N=C1)NC2=NNC(=C2)C=3C(OC)=CC=CC3OCCCN.O=S(=O)(O)C

-20°C

Ice Packs

Small Compound