PRGL493 - CAS 2479378-45-3

PRGL493 is an inhibitor of long-chain acyl-CoA synthetase 4 (ACSL4) .1It inhibits formation of arachidonoyl-CoA (AA-CoA) from arachidonic acid in, as well as the proliferation and migration of, PC3 and MDA-MB-231 cancer cells when used at a concentration of 50 μM. PRGL493 (5 μM) reduces production of progesterone induced by 8-Br-cyclic AMP (8-Br-cAMP) in MA-10 Leydig tumor cells. It inhibits tumor growth in a PC3 mouse xenograft model when administered at a dose of 0.25 mg/kg.

Ferroptosis, Others

Others, Apoptosis

2479330

0.9911

C25H21N7O2

451.48

CC(=O)NC1=NC(N2C(Nc3ccccc23)=N1)c1cn(nc1-c1ccc(C)o1)-c1ccccc1

-20°C

Ice Packs

Small Compound