PRMT5-IN-28 - CAS 2242753-66-6

PRMT5-IN-28 (compound 36) serves as an inhibitor of the protein arginine methyltransferase 5 (PRMT5) enzyme, which is involved in gene transcription, mRNA splicing, DNA repair, protein localization, cell fate determination, and signal transduction. Dysregulated PRMT5 activity contributes to oncogenesis by promoting cancer cell proliferation, apoptosis resistance, invasion, metastasis, and impacting immune evasion [1].

Histone Methyltransferase

Chromatin/Epigenetic

2242681

C18H19ClN4O5

406.82

O[C@H]1[C@H](N2C3=C(C=C2)C(=NOC)N=CN3)O[C@]([C@H](O)C4=CC=C(Cl)C=C4)([C@H]1O)[H]

-20°C

Ice Packs

Small Compound