PRMT5-IN-50 - CAS 3002409-47-1

PRMT5-IN-50 is an orally active selective inhibitor of PRMT5, demonstrating good metabolic stability and low clearance in human liver microsomes. It inhibits SDMA/HCT116-MTAPdel and SDMA/HCT116-MTAPwt with IC50 values for symmetric arginine methylation inhibition at 1.0 and 536 nM, respectively, and antiproliferative IC50 values at 19 and 1620 nM, respectively. Additionally, PRMT5-IN-50 suppresses tumor growth in mice.

Histone Methyltransferase

Chromatin/Epigenetic

3002361

C26H23F3N6O

492.496

C(N(CC1=CC=C(C(F)(F)F)C=N1)[C@H](C)C=2N=CC=CN2)(=O)C3=CC4=C(N=C(N)C(=C4)C5CC5)C=C3

-20°C

Ice Packs

Small Compound