PRMT5-MTA-IN-1 - CAS 3048425-88-0

PRMT5-MTA-IN-1 (Compound A9a) is an inhibitor of the protein arginine methyltransferase PRMT5-MTA. It suppresses the proliferation of colorectal cancer cells HCT116, both wild-type and MTAP del mutants, with IC50 values of 16 nM and 2.47 μM, respectively. Additionally, PRMT5-MTA-IN-1 demonstrates favorable hepatic microsomal stability, membrane permeability, and pharmacokinetic properties in CD-1 mice.

Histone Methyltransferase

Chromatin/Epigenetic

3048337

C22H19F4N3O3

449.4

CC=1C2=C(N=C(N)C1CO)C=C(F)C(C(N(C)[C@H]3C=4C(OC3)=CC(C(F)(F)F)=CC4)=O)=C2

-20°C

Ice Packs

Small Compound