PRMT5-MTA-IN-3 - CAS 3028674-29-2

PRMT5-MTA-IN-3 (Compound P2A) is an orally active and selective inhibitor of protein arginine methyltransferase 5 (PRMT5) . It inhibits the proliferation of MTAP-deficient colorectal cancer HCT-116 cell line with an IC50 value of 5 nM. PRMT5-MTA-IN-3 holds potential for research in cancers, particularly in MTAP-deficient tumors such as colorectal cancer, non-small cell lung cancer, and pancreatic cancer.

Histone Methyltransferase

Chromatin/Epigenetic

3028643

C19H17F3N6O3

434.372

N(C(C(NC1=C2C(N(C)N=C2)=C(N)N=C1)=O)=O)(C)[C@H]3C=4C(=CC(C(F)(F)F)=CC4)OC3

-20°C

Ice Packs

Small Compound