PRMT5-MTA-IN-4 - CAS 3025838-18-7

PRMT5-MTA-IN-4 (Compound 30) is a potent irreversible inhibitor of protein arginine methyltransferase 5 (PRMT5) with an IC50 of 8 nM. It obstructs arginine methylation, hinders ribosomal RNA processing, and suppresses cell cycle-related protein expression. This compound shows antiproliferative activity in various tumor cell lines, exemplified by an IC50 of 0.3 μM in DLD-1 cells. PRMT5-MTA-IN-4 holds potential for research into hematological malignancies such as acute myeloid leukemia and diffuse large B-cell lymphoma.

Histone Methyltransferase

Chromatin/Epigenetic

3025813

C26H22ClFN6O2

504.94

N#CC1=C(OC2(C)CC2)C=C(Cl)C(F)=C1C3=C(C=NN3C)C=4C=C(C=C)C=5C(=O)NN=C(C5C4)CN

-20°C

Ice Packs

Small Compound