PRN694 - CAS 1575818-46-0

PRN694 shows extended target residence time on ITK and RLK, enabling durable attenuation of effector cells in vitro and in vivo. PRN694 is an irreversible, highly selective, and effective covalent interleukin-2-inducible T-cell kinase (ITK) and resting lymphocyte kinase (RLK) dual inhibitor (IC50s: 0.3 nM and 1.4 nM, respectively) .

Others, Tyrosine Kinases

Tyrosine Kinase/Adaptors, Others

1575772

C28H35F2N5O2S

543.67

C[C@H](NCc1ccc2n(C[C@H]3CCCN3C(=O)C=C)c(NC(=O)c3ccc(s3)C(F)F)nc2c1)C(C)(C)C

-20°C

Ice Packs

Small Compound