Pro-FTY - CAS 3064707-13-4

Pro-FTY is an anticancer prodrug of FTY720 and acts as a sphingosine-1-phosphate (S1P) inhibitor. It specifically inhibits S1P signaling in cancer cells via a drug delivery system (DDS) that reacts with acrolein. pro-FTY significantly reduces the survival of breast cancer cells, including multidrug-resistant cells and organoids resistant to Paclitaxel or Doxorubicin. Additionally, pro-FTY effectively suppresses tumor growth in xenograft mouse models of 4T1 cells or organoids while avoiding lymphopenia.

LPL Receptor, STAT

GPCR/G Protein, JAK/STAT signaling, Stem Cells

3064690

C33H50N4O4

566.77

[N-]=[N+]=NC=1C(=CC(=CC1C(C)C)COC(=O)NC(CO)(CO)CCC2=CC=C(C=C2)CCCCCCCC)C(C)C

-20°C

Ice Packs

Small Compound