Proadrenomedullin (1-20), human - CAS 150238-87-2

Endogenous peptide agonist of Mas related GPR X2 (MRGPRX2, EC50 = 251 nM) . Also a noncompetitive nicotinic cholinergic antagonist. Inhibits nicotine-stimulated catecholamine secretion from PC12 cells in vitro, and from sympathetic nerve endings and adrenal chromaffin cells in vivo. Corresponds to amino acids 1 - 20 of proadrenomedullin. Antihypertensive.

AChR

Neuroscience

150149

C112H178N36O27

2460.84

C([C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC1=CC=CC=C1)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CCCNC(=N)N)NC([C@H](C)N)=O)=O)CC(C)C)=O)CC(O)=O)=O)[C@H](C)C)=O)C)=O)CO)=O)CCC(O)=O)=O)=O)CCCNC(=N)N)=O)CCCCN)=O)CCCCN)=O)C(N[C@H](C(N[C@H](C(N[C@@H](CC=2C=3C(NC2)=CC=CC3)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCCNC(=N)N)C(N)=O)=O)CO)=O)CC(C)C)=O)C)=O)=O)CCCCN)=O)CC(N)=O)=O)C=4C=5C(NC4)=CC=CC5

-20°C

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Peptide