Procarbazine hydrochloride - CAS 366-70-1

Procarbazine hydrochloride (NSC-77213 HCl) is the hydrochloride salt of a methylhydrazine derivative with antineoplastic and mutagenic activities. Although the exact mode of cytotoxicity has not been elucidated, procarbazine, after metabolic activation, appears to inhibit the trans-methylation of methionine into transfer RNA (t-RNA), thereby preventing protein synthesis and consequently DNA and RNA synthesis. This agent may also undergo auto-oxidation, resulting in the formation of cytotoxic free radicals which damage DNA through an alkylation reaction.

DNA Alkylator/Crosslinker, DNA/RNA Synthesis

DNA Damage/DNA Repair, Cell Cycle/Checkpoint

295

0.98

C12H19N3O·HCl

257.76

c1(C(=O)NC(C)C)ccc(cc1)CNNC.Cl

-20°C

Ice Packs

Small Compound