Proguanil - CAS 500-92-5

Proguanil (Chloroguanide) is a prophylactic antimalarial drug that acts primarily through its active metabolite, Cycloguanil, which inhibits the dihydrofolate reductase (DHFR) enzyme of Plasmodium falciparum, preventing the synthesis of purines and pyrimidines and inhibiting the growth and reproduction of the parasite.

Parasite, DNA/RNA Synthesis, Antifolate

DNA Damage/DNA Repair, Cell Cycle/Checkpoint, Microbiology/Virology

403

0.996

C11H16ClN5

253.73

ClC1=CC=C(C=C1)NC(=N)NC(=N)NC(C)C

-20°C

Ice Packs

Small Compound