Pronqodine A - CAS 1424195-39-0

Pronqodine A is a quinone isolated from Streptomyces, known for its enzyme inhibitory and anti-inflammatory properties. It targets NAD (P) H:quinone acceptor oxidoreductase 1 (NQO1; IC50 = 131.5 nM) . In SW 982 human synovial sarcoma cells, it suppresses bradykinin-induced production of prostaglandin E2 (PGE2), 6-keto PGF1α, and PGD2, with IC50 values of 9, 19, and 7 nM, respectively, and it also promotes the generation of reactive oxygen species (ROS) in these cells.

Others, ROS, Reductase, Indoleamine 2,3-Dioxygenase (IDO), IDO

Metabolism, Immunology/Inflammation, Others, Endocrinology/Hormones

1424195-39-0

C8H6N2O2S

194.21

O=C1C=C(NC)C(=O)C=2C=NSC12

-20°C

Ice Packs

Natural Product