Propargyl-PEG1-acid - CAS 55683-37-9

Propargyl-PEG1-acid, a PEG-based PROTAC linker, enables the synthesis of BTK-CRBN PROTACs, specifically Ibrutinib-based PROTAC 4 and PROTAC 5. At a concentration of 10 μM, PROTAC 5 facilitates the degradation of BTK and induces the degradation of CSK, LYN, and LAT2[1].

PROTAC Linker, Others

Others, PROTAC

55637

C6H8O3

128.13

OC(=O)CCOCC#C

-20°C

Ice Packs

PROTAC