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Propargyl-PEG4-acid - CAS 1415800-32-6

Propargyl-PEG4-acid - CAS 1415800-32-6

MF-0033845-01

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Product Details

  • Bioactivity

    Propargyl-PEG4-acid is a PEG-based PROTAC linker used in the synthesis of BTK-IAP PROTACs, including Ibrutinib-based PROTAC 2 and its analogue PROTAC 3. PROTAC 3 induces BTK degradation with a DC50 of 200 nM in THP-1 cells[1].

  • Target

    Others, PROTAC Linker

  • Related Pathways

    Others, PROTAC

  • CAS Number

    1415762

  • Molecular Formula

    C12H20O6

  • Molecular Weight

    260.28

  • SMILES

    C(OCCOCCOCC#C)COCCC(O)=O

  • Storage Temperature

    -20°C

  • Shipping Conditions

    Ice Packs

  • Category

    PROTAC