Prosaptide TX14 (A) - CAS 196391-82-9

Potent GPR37L1 and GPR37 agonist (EC50 values are 5 and 7 nM, respectively) . Stimulates signaling through pertussis toxin-sensitive G proteins. Stimulates ERK phosphorylation. Protects against cellular stress. Promotes myelin lipid synthesis and prolongs cell survival in both Schwann cells and oligodendrocytes; neuroprotective and glioprotective.

Orphan Receptor

GPCR/G Protein

196300

C69H110N16O26

1579.72

[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC1=CC=C(O)C=C1)C(O)=O)=O)CC(C)C)=O)[C@H](CC)C)=O)(NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](NC([C@H]([C@@H](C)O)N)=O)C)=O)CC(C)C)=O)[C@H](CC)C)=O)CC(O)=O)=O)CC(N)=O)=O)CC(N)=O)=O)C)=O)[C@@H](C)O)=O)CCC(O)=O)=O)CCC(O)=O

-20°C

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Peptide