Prostratin - CAS 60857-08-1

Prostratin (12-Deoxyphorbol-13-acetate) is an orally active protein kinase C (PKC) activator with a Ki value of 12.5 nM.As an NF-κB activator, Prostratin activates HIV gene expression in T cells.Prostratin inhibits the growth of acute myeloid leukemia (AML) cell lines and enhances cytarabine-induced AML cell differentiation. In addition, Prostratin induced KRAS phosphorylation and inhibited the growth of KRAS-mutated tumors.

PKC, Kras, NF-κB, HIV Protease, Ras

Proteases/Proteasome, NF-κB, Chromatin/Epigenetic, Cytoskeletal Signaling, MAPK, Microbiology/Virology, GPCR/G Protein

60857-08-1

C22H30O6

390.47

O(C(C)=O)[C@@]12[C@@](C1(C)C)([C@]3([C@](O)([C@H](C)C2)[C@]4([C@](O)(CC(CO)=C3)C(=O)C(C)=C4)[H])[H])[H]

-20°C

Ice Packs

Natural Product