PROTAC ALK degrader-1 - CAS 3049802-45-8

PROTACALK degrader-1 (compound B1) is a PROTACs-based ALK degrader with a DC50 of 26 nM in H3122 EML4-ALK. It is utilized in creating PROTACALK degrader-2, which boasts excellent bioavailability.

PROTACs, ALK

Angiogenesis, PROTAC, Tyrosine Kinase/Adaptors

3049749

C47H55ClN10O9S

971.52

O=C1NC(=O)C(N2C(=O)C=3C=CC=C(NCCNC(=O)CNC(=O)CN4CCC(C5=CC(OC(C)C)=C(C=C5C)NC6=NC=C(Cl)C(=N6)NC=7C=CC=CC7S(=O)(=O)C(C)C)CC4)C3C2=O)CC1

-20°C

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PROTAC