PROTAC AR-V7 degrader-1 - CAS 2767440-24-2

PROTAC AR-V7 degrader-1 (Compound 6) is an orally bioavailable, potent, and selective degrader targeting the androgen receptor (AR) variant V7, achieving degradation with a DC50 of 0.32 μM by directing the VHL E3 ligase to the AR DNA-binding domain (DBD) . It demonstrates efficacy in the 22Rv1 cell line expressing AR-V7, with an EC50 of 0.88 μM [1].

PROTACs, Androgen Receptor

Endocrinology/Hormones, PROTAC

2767414

C41H52N6O6S2

789.02

C([C@@H](NC(CCCCOC1=CC=C(C=C1)C=2N=C(SC2)N3CCOCC3)=O)[C@@](C)(C)C)(=O)N4[C@H](C(N[C@@H](C)C5=CC=C(C=C5)C=6SC=NC6C)=O)C[C@@H](O)C4

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