PROTAC ATR degrader-1 - CAS 2925916-30-7

PROTAC ATR degrader-1 (compound ZS-7) serves as a powerful PROTAC degrader targeting ataxia telangiectasia and Rad3-related (ATR), exhibiting a DC50 of 0.53 μM. This compound is significant in the field of cancer research [1].

PROTACs, ATM/ATR

PROTAC, PI3K/Akt/mTOR signaling, DNA Damage/DNA Repair

2925916-30-7

C46H52N12O8S

933.05

S(=NC(CCC1=CN(CCCCCCCC(NC2=C3C(C(=O)N(C3=O)C4C(=O)NC(=O)CC4)=CC=C2)=O)N=N1)=O)(C)(=O)C5(CC5)C6=NC(=NC(=C6)N7[C@H](C)COCC7)C8=C9C(=NC=C8)NC=C9

-20°C

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PROTAC