PROTAC ATR degrader-2 - CAS 3010273-12-5

PROTAC ATR degrader-2 (Compound 8i) serves as a PROTAC degrader targeting ATR, effectively degrading it in acute myeloid leukemia (AML) cell lines MV-4-11 and MOLM-13, with DC50 values of 22.9 and 34.5 nM, respectively. This compound induces apoptosis and inhibits the proliferation of AML cells. Additionally, PROTAC ATR degrader-2 demonstrates favorable pharmacokinetic properties and potent antitumor activity in a mouse model of AML.

PROTACs, Apoptosis

PROTAC, Apoptosis

3010273-12-5

C40H41N9O6

743.81

N(C(CCCCN1CCN(C(=O)C2=CC=C(C=C2)C3=NC(C(NC4=CC=CC=C4)=O)=C(N)N=C3)CC1)=O)C5=C6C(C(=O)N(C6)C7C(=O)NC(=O)CC7)=CC=C5

-20°C

Ice Packs

PROTAC