PROTAC Bcl-xL degrader-4 - CAS 2930759-37-6

PROTACBcl-xL degrader-4 (Compound 2-38-III) is a Bcl-xL PROTAC degrader with significant antitumor activity against HepG2 and HUVEC cells. It induces apoptosis by reducing mitochondrial membrane potential and activating the MAPK signaling pathway. PROTACBcl-xL degrader-4 markedly inhibits tumor growth in xenograft mouse models.

Mitochondrial Metabolism, ROS, JNK, ERK, PROTACs, Apoptosis, Bcl-2 Family, p38 MAPK

Immunology/Inflammation, Apoptosis, Metabolism, PROTAC, MAPK

2930716

C39H34N4O9

702.71

O=C(OCCOCCOCCNC1=CC=CC=2C(=O)N(C(=O)C12)C3C(=O)NC(=O)CC3)C4=CC=C5NC(=CC(=O)C5=C4)C=6C=CC=C7C=CC=CC76

-20°C

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PROTAC