PROTAC BCR-ABL1 ligand 1 - CAS 2489876-34-6

GMB-475, also known as PROTAC BCR-ABL1 ligand 1, allosterically targets and binds to the BCR-ABL1 protein. It effectively recruits the E3 ligase Von Hippel-Lindau, leading to the ubiquitination and subsequent degradation of BCR-ABL1 [1].

Others, Bcr-Abl

Cytoskeletal Signaling, Tyrosine Kinase/Adaptors, Others, Angiogenesis

2489836

C17H12F3N3O2

347.29

N(C1=CC(C2=CC=C(O)C=C2)=NC=N1)C3=CC=C(OC(F)(F)F)C=C3

-20°C

Ice Packs

Small Compound