PROTAC BRD4 Degrader-12 - CAS 2417370-90-0

PROTAC BRD4 Degrader-12 (compound 9c) is a PROTAC that links von Hippel-Lindau and BRD4 ligands. When conjugated with STEAP1 and CLL1 antibodies, this compound effectively degrades BRD4 protein in PC3 prostate cancer cells, demonstrating potent activity with DC50 values of 0.39 nM and 0.24 nM, respectively [1].

Epigenetic Reader Domain, PROTAC-Linker Conjugates for PAC, PROTACs, Others

PROTAC, Chromatin/Epigenetic, Antibody-drug Conjugate/ADC Related, Others

2417280

C62H77F2N9O12S4

1306.58

CC(OC(=O)O[C@@H]1C[C@H](N(C1)C(=O)[C@@H](NC(=O)CCCCCCCCCCNC(=O)c1cc2N(Cc3c[nH]c4c3c(cn(C)c4=O)-c2cc1CS(C)(=O)=O)c1ncc(F)cc1F)C(C)(C)C)C(=O)NCc1ccc(cc1)-c1scnc1C)C(C)SS(C)(=O)=O

-20°C

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PROTAC