PROTAC BRD4 Degrader-9 - CAS 2417370-42-2

PROTAC BRD4 Degrader-9 (compound 8a) is a novel chemical compound comprising ligands for von Hippel-Lindau and BRD4, connected by a PROTAC moiety. This compound efficiently degrades the BRD4 protein in PC3 prostate cancer cells. When conjugated with STEAP1 and CLL1 antibodies, PROTAC BRD4 Degrader-9 exhibits potent activity, with respective DC50 values of 0.86 nM and 7.6 nM.

Epigenetic Reader Domain, PROTACs, Others

Others, Chromatin/Epigenetic, PROTAC

2417326

C59H71F2N9O15S4

1312.5

Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@H](CN2C(=O)[C@@H](NC(=O)COCCOCCOCCNC(=O)c2cc3N(Cc4c[nH]c5c4c(cn(C)c5=O)-c3cc2CS(C)(=O)=O)c2ncc(F)cc2F)C(C)(C)C)OC(=O)OCC(C)(C)SS(C)(=O)=O)cc1

-20°C

Ice Packs

PROTAC