PROTAC BRM degrader-1 - CAS 2378051-80-8

PROTAC BRM degrader-1 (compound 17) serves as a PROTAC-based degrader targeting both BRM and BRG1, exhibiting DC50 values of 93 pM and 4.9 nM, respectively [1].

PROTACs, Epigenetic Reader Domain

PROTAC, Chromatin/Epigenetic

2378051-80-8

C57H69N11O8S

1068.29

O(C1=CC(N2C3CN(CC2CC3)C=4C=C(N=NC4N)C5=C(O)C=CC=C5)=CC=N1)[C@@H]6C[C@@H](OC7CCN(CCOC=8C=C([C@H](C(=O)N9[C@H](C(N[C@@H](C)C%10=CC=C(C=C%10)C=%11SC=NC%11C)=O)C[C@@H](O)C9)C(C)C)ON8)CC7)C6

-20°C

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PROTAC