PROTAC BTK Degrader-1 - CAS 2801715-13-7

PROTAC BTK Degrader-1, a powerful, selective, and orally bioavailable degrader of PROTAC BTK, demonstrates effective reduction in BTK protein levels and tumor suppression. It exhibits IC50 values of 34.51 nM for BTK WT and 64.56 nM for BTK-481S, highlighting its potency and efficacy in targeting and diminishing BTK protein abundance [1].

Others, BTK, PROTACs

Angiogenesis, Tyrosine Kinase/Adaptors, PROTAC, Others

2801695

C43H43N9O4

749.86

Nc1ncnc2n(nc(-c3ccc(Oc4ccccc4)cc3)c12)C1CCN(CC1)C1CCN(CC#Cc2ccc3C(=O)N(Cc3c2)C2CCC(=O)NC2=O)CC1

-20°C

Ice Packs

PROTAC