PROTAC c-Met degrader-1 - CAS 3056647-52-7

PROTACc-Met degrader-1 (Compound Met-DD4) is an orally effective PROTAC degrader targeting c-Met with a DC50 of 6.21 nM. It inhibits the proliferation of c-Met-addicted MKN-45 cells with an IC50 of 4.37 nM and causes cell cycle arrest in the G0/G1 phase. In a xenograft mouse model using MKN-45 cells, PROTACc-Met degrader-1 demonstrates antitumor activity.

C-Met/HGFR, PROTACs

Tyrosine Kinase/Adaptors, PROTAC

3056588

C45H41FN10O5

820.87

O=C1C2=CC=C(C=C2C(=O)N1C3C(=O)NC(=O)CC3)N4CCN(CC4)CC5CCN(C(=O)C=6C=CC(=CC6F)C7=NN8C(N=C7)=NC=C8CC9=CC=C%10N=CC=CC%10=C9)CC5

-20°C

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