PROTAC CDK2 Degrader-1 - CAS 3024971-78-3

PROTAC CDK2 Degrader-1 (Compound 41) is a PROTAC degrader targeting cyclin-dependent kinase 2 (CDK2) . It inhibits the phosphorylation of the RB protein in the CDK2-dependent cell line OVCAR3, with an IC50 ranging from 100-500 nM.

PROTACs, CDK

PROTAC, Cell Cycle/Checkpoint

3024890

C38H46F6N12O4S

880.91

O=C1NC(=O)CCN1C2=NN(C=3C=C(C=CC23)C4CCN(CC4)CC5CCN(CC5)S(=O)(=O)N6CCC(NC=7N=CC(=C(N7)C=8C=NN(C8)CC(F)(F)F)C(F)(F)F)CC6)C

-20°C

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PROTAC