PROTAC CDK9 degrader-5 - CAS 2935587-89-4

PROTAC CDK9 degrader-5 is a selective PROTAC that mediates degradation of CDK9 via the proteasome pathway, efficiently degrading CDK9 42 and CDK9 55 isoforms with DC50 values of 0.10 μM and 0.14 μM, respectively [1].

CDK, PROTACs

PROTAC, Cell Cycle/Checkpoint

2935494

C42H48Cl2N8O9

879.78

O=C1C=2C(C(=O)N1C3C(=O)NC(=O)CC3)=CC=CC2OCC(NCCCCCCCCCCC(=O)N4CCC(NC(=O)C=5C(NC(=O)C6=C(Cl)C=CC=C6Cl)=CNN5)CC4)=O

-20°C

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PROTAC