PROTAC CYP1B1 degrader-1 - CAS 2411389-67-6

PROTAC CYP1B1 Degrader-1 (Compound 6C), an α-naphthoflavone chimera derivative, effectively targets and degrades cytochrome P450 (CYP) 1B1 to overcome agent resistance, displaying half-maximal inhibitory concentrations (IC50s) of 95.1 nM for CYP1B1 and 9838.6 nM for CYP1A2. This compound is suitable for investigating prostate cancer characterized by overexpression of CYP1B1 [1].

PROTACs, Cytochromes P450

PROTAC, Metabolism

2411316

C43H39N5O10

785.8

COc1ccc(OC)c2c1c(OC)cc1c2oc(cc1=O)-c1ccc(cc1)-c1cn(CCCCCCOc2cccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c23)nn1

-20°C

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PROTAC