PROTAC EGFR degrader 11 - CAS 3034244-71-5

PROTAC EGFR degrader 11 (Compound B71) is a PROTAC degrader targeting the epidermal growth factor receptor (EGFR), with a DC50 of less than 100 nM. It binds to CRBN-DDB1 with a Ki of 36 nM. This compound effectively degrades EGFR, focal adhesion kinase (FAK), and RSK1, and inhibits the proliferation of BaF3 wild-type and EGFR mutant cells, exhibiting an IC50 of less than 100 nM.

EGFR, FAK, PROTACs

Angiogenesis, JAK/STAT signaling, Tyrosine Kinase/Adaptors, Cytoskeletal Signaling, PROTAC

3034244-71-5

C49H64ClFN10O7S

991.61

O=C1NC(=O)C(C2=CC=C(C=C2F)N3CCC(OCCN4CCN(CC4)C5CCN(C6=CC(OC)=C(C=C6CC)NC7=NC=C(Cl)C(=N7)NC8=CC=C(OC)C=C8N(C)S(=O)(=O)C)CC5)CC3)CC1

-20°C

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PROTAC