PROTAC EGFR degrader 3 - CAS 2768472-28-0

PROTAC EGFR Degrader 3, a highly potent molecule, exhibits remarkable cellular activity against H1975 and HCC827 cells, maintaining high selectivity. It additionally reveals the lysosome's crucial role in the degradation mechanism of mutant EGFR [1].

PROTACs, EGFR

Tyrosine Kinase/Adaptors, PROTAC, Angiogenesis, JAK/STAT signaling

2768444

C60H77N13O5S

1092.4

C[C@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H](NC(=O)CCCCCCCN1CCN(CC1)c1ccc(Nc2ncc3nc(Nc4ccccc4)n([C@H]4CCCN(C4)C(=O)C=C)c3n2)cc1)C(C)(C)C)c1ccc(cc1)-c1scnc1C

-20°C

Ice Packs

PROTAC