PROTAC EGFR degrader 4 - CAS 2882845-50-1

PROTAC EGFR degrader 4 is a potent molecule designed to target and degrade mutant EGFR, effectively inducing degradation of EGFR del19 and EGFR L858R/T790M with DC50 values of 0.51 nM and 126 nM, respectively. It significantly inhibits the growth of HCC827 and H1975 cell lines, demonstrating IC50 values of 0.83 nM and 203.1 nM, respectively. The induced degradation of EGFR by this compound is associated with autophagy [1].

Others, EGFR, Autophagy, PROTACs

Angiogenesis, Others, Autophagy, PROTAC, Tyrosine Kinase/Adaptors, JAK/STAT signaling

2882794

C55H70N12O4S

995.29

Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCCN2CCN(CC2)c2ccc(Nc3ncc4nc(Nc5ccccc5)n(C5CCCC5)c4n3)cc2)C(C)(C)C)cc1

-20°C

Ice Packs

PROTAC