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Molfinity

PROTAC EGFR degrader 6 - CAS 2409793-28-6

PROTAC EGFR degrader 6 - CAS 2409793-28-6

MF-0154802-01

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Product Details

  • Bioactivity

    PROTAC EGFR degrader 6 is a potent PROTAC EGFR degrader that effectively reduces EGFR Del19 levels in HCC827 cells, exhibiting a DC50 of 45.2 nM. It notably promotes apoptosis and induces G1 phase arrest in HCC827 cells [1].

  • Target

    Others, PROTACs, Apoptosis, EGFR

  • Related Pathways

    Angiogenesis, Tyrosine Kinase/Adaptors, Apoptosis, Others, PROTAC, JAK/STAT signaling

  • CAS Number

    2409759

  • Molecular Formula

    C49H57FN12O5

  • Molecular Weight

    913.05

  • SMILES

    OCC1CCN(CC1)c1nc(Nc2ccc(F)cc2)nc2cnc(Nc3ccc(cn3)N3CCN(CCCCCCCC(=O)Nc4cccc5C(=O)N(Cc45)C4CCC(=O)NC4=O)CC3)cc12

  • Storage Temperature

    -20°C

  • Shipping Conditions

    Ice Packs

  • Category

    PROTAC