PROTAC EGFR degrader 8 - CAS 2925923-46-0

PROTAC EGFR degrader 8 (T-184) is a PROTAC that selectively degrades the epidermal growth factor receptor (EGFR) with a DC50 of 15.56 nM in HCC827 cells, and inhibits the growth of cell lines H1975, PC-9, and HCC827 with IC50 values of 7.72 nM, 121.9 nM, and 14.21 nM, respectively. This compound is used primarily for cancer research, particularly in the context of non-small cell lung cancer (NSCLC) [1].

EGFR, PROTACs

Angiogenesis, JAK/STAT signaling, Tyrosine Kinase/Adaptors, PROTAC

2925877

C40H46ClN11O5

796.32

O(C)C=1C=C(C=CC1NC=2N=C(NC3=C(C(NC)=O)C=CC=C3)C(Cl)=CN2)N4CCN(C(CN5CCN(CC5)C6=CC=C(NC7C(=O)NC(=O)CC7)C=C6)=O)CC4

-20°C

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PROTAC