PROTAC EGFR degrader 9 - CAS 2992670-33-2

PROTACEGFRdegrader 9 (Compound C6) is an orally active, CRBN-based PROTAC EGFR degrader. It has a DC50 of 10.2 nM and a Kd of 240.2 nM against EGFRL858R/T790M/C797S. PROTACEGFRdegrader 9 demonstrates effective degradation activity against various EGFR mutants while not affecting EGFRWT.

PROTACs, Apoptosis, EGFR

Tyrosine Kinase/Adaptors, Angiogenesis, Apoptosis, JAK/STAT signaling, PROTAC

2992635

C45H48F3N9O6S

899.98

O=C1C=2C=CC=C(NC(=O)CCCCCCN3CCN(C4=CC=C(C=C4)NC=5N=CC(=C(N5)C6=CN(C=7C=CC=CC67)S(=O)(=O)CC)C(F)(F)F)CC3)C2CN1C8C(=O)NC(=O)CC8

-20°C

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PROTAC