PROTAC ERα Degrader-10 - CAS 2421260-43-5

PROTACERα Degrader-10 (Compound 160a) is an orally bioavailable ERα degrader with a DC50 of 0.37-1.1 nM in MCF7, T47D, and CAMA-1 cells. It demonstrates antitumor activity in mouse models.

Estrogen Receptor/ERR, PROTACs

Endocrinology/Hormones, PROTAC

2421212

C45H49N5O4

723.9

C(=C(/CC)\C1=CC=CC=C1)(\C2=CC=C(C=C2)N3CCC(CN4CCN(CC4)C=5C=C6C(=CC5)C(=O)N(C6)[C@@H]7C(=O)NC(=O)CC7)CC3)/C8=CC=C(O)C=C8

-20°C

Ice Packs

PROTAC