PROTAC ER Degrader-14 - CAS 2504911-73-1

PROTAC ER Degrader-14 (compound 86) is a PROTAC-type estrogen receptor/ERR degrader. It comprises an E3 ubiquitin ligase ligand (blue part) (S) -Deoxy-thalidomide, a PROTAC linker (black part) N-Boc-piperazine, and a target protein ligand (red part) ER ligand-6. The combination of the E3 ligase and linker forms tert-Butyl (S) -4- (2- (2,6-dioxopiperidin-3-yl) -1-oxoisoindolin-5-yl) piperazine-1-carboxylate.

PROTACs, Estrogen Receptor/ERR

PROTAC, Endocrinology/Hormones

2504837

C44H46FN5O5

743.865

FC=1C=C([C@H]2[C@H](COC=3C2=CC=C(O)C3)C4=CC=CC=C4)C=CC1N5CCC(CN6CCN(CC6)C=7C=C8C(=CC7)C(=O)N(C8)[C@@H]9C(=O)NC(=O)CC9)CC5

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