PROTAC ERα Degrader-2 - CAS 1351169-29-3

PROTAC ERα Degrader-2 is composed of a cIAP1 ligand binding group, a linker, and an estrogen receptor α (ERα) binding group, serving as an ERα degrader. It achieves maximal ERα degradation in human mammary tumor MCF7 cells at a concentration of 30 μM. Degradation inducers that utilize cIAP1 are referred to as specific and non-genetic IAP-dependent protein erasers (SNIPERs) [1].

PROTACs, SNIPERs, Estrogen Receptor/ERR

PROTAC, Endocrinology/Hormones

1351137

C42H61N5O8

763.96

C[C@@]1\2[C@]([C@]3([C@@](C=4C(CC3)=CC(O)=CC4)(CC1)[H])[H])(CC/C2=N\OCC(NCCOCCOCCNC([C@@H](NC([C@H]([C@@H](CC5=CC=CC=C5)N)O)=O)CC(C)C)=O)=O)[H]

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