PROTAC EZH2 Degrader-1 - CAS 2641601-67-2

PROTAC EZH2 Degrader-1 (Compound 150d) is a potent PROTAC molecule that effectively suppresses EZH2 methyltransferase activity, with a half-maximal IC50 of 2.7 nM. EZH2 is a histone methyltransferase crucial to tumorigenesis and cancer progression, and PROTAC EZH2 Degrader-1 represents an important chemical tool for probing its therapeutic relevance.

PROTACs, Histone Methyltransferase

Chromatin/Epigenetic, PROTAC

2641532

C54H67N7O8

942.15

O=C(NCC=1C(=O)NC(=CC1C)C)C2=CC(=CC(=C2C)N(CC)C3CCOCC3)C4=CC=C(C=C4)CN5CCN(CC5)CCCCCCCOC6=CC=CC=7C(=O)N(C(=O)C67)C8C(=O)NC(=O)CC8

-20°C

Ice Packs

PROTAC