PROTAC FLT-3 degrader 1 - CAS 2230826-81-8

PROTAC FLT-3 degrader 1 is a PROTAC FLT-3 degrader of internal tandem duplication (ITD) with an IC50 of 0.6 nM and exhibits anti-proliferative activity.

Apoptosis, PROTACs, FLT, STAT, ERK, MEK

Stem Cells, Apoptosis, PROTAC, Tyrosine Kinase/Adaptors, Angiogenesis, JAK/STAT signaling, MAPK

2230826-81-8

C52H61N9O9S2

1020.23

O(CCOCCOCCC(N[C@H](C(=O)N1[C@H](C(NCC2=CC=C(C=C2)C3=C(C)N=CS3)=O)C[C@@H](O)C1)C(C)(C)C)=O)C=4C=C5C(N6C(S5)=NC(=C6)C7=CC=C(NC(NC=8C=C(C(C)(C)C)ON8)=O)C=C7)=CC4

-20°C

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