PROTAC FLT3/JAK2/BRD4 Degrader-1 - CAS 3067695-20-6

PROTACFLT3/JAK2/BRD4 Degrader-1 is a PROTAC degrader targeting FLT3, JAK2, and BRD4, with DC50 values of 5.23 nM, 0.678 nM, and 1.17 nM, respectively. It exhibits potent antiproliferative activity against MV4;11 cells (IC50= 0.79 nM) and FLT3-mutated Ba/F3 cells. Additionally, PROTACFLT3/JAK2/BRD4 Degrader-1 induces apoptosis in MV4;11 cells and demonstrates significant antitumor efficacy in an MV4;11 xenograft model established in NOD SCID mice. This compound is applicable for research in acute myeloid leukemia (AML) .

FLT, PROTACs, Epigenetic Reader Domain, JAK

Chromatin/Epigenetic, PROTAC, Tyrosine Kinase/Adaptors, JAK/STAT signaling, Angiogenesis, Stem Cells

3067669

C44H51FN10O7S

883

O=C1NC(=O)C(N2C(=O)C3=CC=C(C=C3C2=O)NCCCCCC(=O)N4CCN(C5=CC=C(C=C5F)NC6=NC=C(C(=N6)NC7=CC=CC(=C7)NS(=O)(=O)C(C)(C)C)C)CC4)CC1

-20°C

Ice Packs

PROTAC