PROTAC GPX4 degrader-1 - CAS 2916433-81-1

PROTAC GPX4 Degrader-1 (DC-2) is a PROTAC-based compound that efficiently degrades GPX4, demonstrating a degradation concentration (DC 50) of 0.03 μM in HT1080 cells [1].

Glutathione Peroxidase, PROTACs, Ferroptosis

PROTAC, Apoptosis, Metabolism

2916351

C50H57ClN10O10

993.5

O=C1C2=C(NCCCN3CCN(CC3)CC4CCN(CC4)C(COC5=CC=C(C=C5)C(C6=CC=C(C=C6)Cl)N7CCN(CC7)C(C8=NOC(C)=C8[N+]([O-])=O)=O)=O)C=CC=C2C(N1C9C(NC(CC9)=O)=O)=O

-20°C

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PROTAC