PROTAC GSPT1 degrader-1 - CAS 3034310-17-0

PROTAC GSPT1 degrader-1 (Compound F) is a PROTAC-based degrader that effectively targets and degrades G1 to S phase transition protein 1 (GSPT1), achieving degradation rates of 95% at 1 μM and 86% at 0.1 μM. Additionally, this compound inhibits the viability of HL-60 cells with an IC50 of 9.2 nM.

PROTACs

PROTAC

3034293

C37H36ClN7O5

694.18

O=C1NC(=O)C(N2C(=O)C3=CC=C(C=C3C2=O)N4CC(C4)CCN5C(=O)N(C=6C=CC=C(C6)C=7C=NC=8NC=C(C8C7Cl)CC)CCC5)CC1

-20°C

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PROTAC