PROTAC HER2 degrader-1 - CAS 2897640-93-4

PROTACHER2 degrader-1 is a highly selective HER2 PROTAC degrader with a DC50 of 69 nM and a Dmax of 96%. It effectively inhibits HER2-positive cell proliferation and tumor growth by inducing sustained HER2 degradation and strongly inhibiting downstream pathways (AKT and ERK) . Additionally, PROTACHER2 degrader-1 can induce apoptosis in BT-474 cells and is useful for researching HER2-positive cancers.

Akt, PROTACs, Apoptosis, ERK, EGFR

PI3K/Akt/mTOR signaling, Angiogenesis, MAPK, Cytoskeletal Signaling, PROTAC, JAK/STAT signaling, Apoptosis, Tyrosine Kinase/Adaptors

2897543

C49H55N11O7

910.03

O=C1C2=CC=C(C=C2C(=O)N1C3C(=O)NC(=O)CC3)NCCCCCCCN4CCN(CC4)CCCOC5=CC6=NC=NC(NC7=CC=C(OC=8C=CN9N=CN=C9C8)C(=C7)C)=C6C=C5OC

-20°C

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PROTAC