PROTAC HSP90 degrader BP3 - CAS 2669072-88-0

PROTAC HSP90 degrader BP3 potently and selectively degrades HSP90 through a CRBN-dependent mechanism. It effectively diminishes HSP90 protein levels in MCF-7 cells with a half-maximal degradation concentration (DC50) of 0.99 μM. Additionally, this compound impedes the proliferation of breast cancer cells [1].

HSP, PROTACs

Cytoskeletal Signaling, Metabolism, PROTAC

2668984

C32H29ClN8O5

641.08

COc1c(C)cnc(Cn2cc(C#CCCNc3cccc4C(=O)N(C5CCC(=O)NC5=O)C(=O)c34)c3c(Cl)nc(N)nc23)c1C

-20°C

Ice Packs

PROTAC