PROTAC IDO1 Degrader-1 - CAS 2488851-89-2

PROTAC IDO1 Degrader-1, a pioneering compound, efficiently targets indoleamine 2,3-dioxygenase 1 (IDO1) for ubiquitination and degradation by recruiting IDO1 to the CRBN E3 ligase, thereby facilitating its entry into the ubiquitin-proteasome system (UPS) with a DC50 of 2.84 μM. This compound also moderately enhances the tumor-killing efficacy of HER2 CAR-T cells[1].

Indoleamine 2,3-Dioxygenase (IDO), PROTACs, IDO

PROTAC, Metabolism

2488760

C40H53BrFN9O13

966.816

O\N=C(/Nc1ccc(F)c(Br)c1)c1nonc1NCCNCCOCCOCCOCCOCCOCCOCCOCCNc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12

-20°C

Ice Packs

PROTAC