PROTAC IRAK4 degrader-10 - CAS 3033829-95-4

PROTACIRAK4 degrader-10 (compound 10) is an orally active PROTAC based on a Cereblon ligand, achieving a maximum degradation rate of 95.94% for IRAK4 in HEK293 cells with a DC50 value of 7.68 nM.

PROTACs, IRAK

Immunology/Inflammation, PROTAC, NF-κB

3033829-95-4

C43H45F3N8O6

826.86

O=C(NC1=CN2C=C(N=C2C(F)=C1C(O)(C)C)C3CCN(CC3)CC4CCN(C5=CC=C6C(=O)N(C(=O)C6=C5)C7C(=O)NC(=O)CC7)CC4)C=8N=C(C=CC8)C9CC9(F)F

-20°C

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